The invention discloses a synthetic method for 2-(6-methoxyquinoline)acetate. The method comprises the following steps: (1) weighing 6-methoxyquinoline and bromoacetic acid, placing the 6-methoxyquinoline and the bromoacetic acid into a round-bottom flask, then carrying out water-bath heating for 15 min until a white solid is generated, continuing heating for 2 h until the color of the solid becomes pink, then stopping heating, adding 200 ml of three-level water and 200 ml of dichloromethane, adjusting a pH value of a water phase to be slightly more than 7 with NaOH with a concentration of 10%, washing the water phase with dichloromethane until no red filtrate is washed out, and subjecting the water phase to spinning drying so as to obtain crude 2-(6-methoxyquinoline)acetate; and (2) adding the obtained crude 2-(6-methoxyquinoline)acetate into methanol and carrying out vibration so that the crude 2-(6-methoxyquinoline)acetate is completely dissolved, then carrying out filtering, and removing remained NaBr so as to obtain the product 2-(6-methoxyquinoline)acetate. The 2-(6-methoxyquinoline)acetate synthesized by using the method provided by the invention has high yield, good crystallization effect and high purity, and provides high-purity standard samples or samples for subsequent chemical and biological experiments.