The invention provides a virtual reality interaction device having a 3D camera assembly. The virtual reality interaction device comprises a 3D camera assembly, a head-mounted virtual reality display, a signal processing assembly and a mobile device interface. The 3D camera assembly is connected with the signal processing assembly and used for capturing an image sequence to be tested, containing depth information, of a user's hands and sending the image sequence to be tested to the signal processing assembly. The signal processing assembly is used for obtaining a gesture of a user based on the image sequence to be tested and determining a corresponding operation instruction based on the gesture in order to execute the operation instruction to a mobile device connected to the mobile device interface. The head-mounted virtual reality display is used for receiving a screen display signal of the mobile device via the mobile device interface such that a screen of the mobile device is present in a pre-set display area in a virtual reality display manner. By adoption of the above technology, the virtual reality interaction device having the 3D camera assembly utilizes gesture recognition technology to perform man-machine interaction. Therefore, an input mode is enriched and operation is performed easily and conveniently.