The invention relates to a nematode killing granule containing avermectin and trichoderma harzianum. The active component of the granule is composed of avermectin and trichoderma harzianum. Trichoderma harzianum technical concentrate with a content of 30 billion cfu/g is taken as the 100% technical concentrate. The weight ratio of avermectin to trichoderma harzianum is 2-15:1-5, the content of avermectin in the composition is 0.2 to 1.5%, and the content of trichoderma harzianum in the composition is 0.03-0.3 billion cfu/g. The granule has a synergetic effect, can effectively prevent and treat nematode, is capable of also improving the micro-environment of soil, can make plant root grow more healthily, and well treats soil-borne diseases such as root rot, southern blight, damping off, rice blight, and the like. The avermectin and trichoderma harzianum can be co-used in a reasonable range, the application amounts of single components are both reduced, the drug resistance of avermectin to the nematode is effectively retarded, the usage period of pesticide is prolonged, moreover, the cost is reduced, and the environmental pollution is reduced.