The invention discloses a layout contact hole pitch amplification method. Layout data adopts a layered structure. The contact hole pitch amplification method for layout data of each layer comprises the following steps of: step 1, according to distribution of contact holes, performing block division on the layout data of each layer; step 2, moving and calculating the contact holes of block data of the layout data of each layer: step 21, extracting a minimum enclosing rectangle of the block data; step 22, by taking 4 vertexes of the minimum enclosing rectangle as reference points, moving the contact holes, calculating the number of the moved contact holes, selecting the vertex with the maximum number of the moved contact holes as a final reference point, and moving the contact holes for pitch amplification of the contact holes. and Step 3, combining the block data after the contact hole pitch amplification. The layout contact hole pitch amplification method can realize design automation, improve the work efficiency and realize repeated use of partial layout data.