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发明授权
CN105153427B 纳米条DOPO‑HQ环三磷腈衍生物及其制备方法 失效 - 权利终止

纳米条DOPO‑HQ环三磷腈衍生物及其制备方法
摘要：
本发明公开了纳米条DOPO‑HQ环三磷腈衍生物，涉及一种DOPO‑HQ环三磷腈衍生物及其制备方法。纳米条DOPO‑HQ环三磷腈衍生物的结构通式如下：其中R为形貌为荧光纳米条，粒径为50nm～200nm。方法如下：一、将干燥的DOPO‑HQ加入四氢呋喃，搅拌至完全溶解；二、然后加入缚酸剂，滴加六氯环三磷腈的四氢呋喃溶液，然后超声回流10～12h；三、然后离心，分别用丙酮、蒸馏水超声洗，得到荧光纳米条DOPO‑HQ环三磷腈衍生物。本发明产品作为靶向给药的载体，可实现药物传递的靶向和荧光示踪目的。
摘要（英）：

The invention discloses a nanometer strip DOPO-HQ cyclotriphosphazene derivative, and relates to a DOPO-HQ cyclotriphosphazene derivative and a preparing method thereof. The general structural formula of the nanometer strip DOPO-HQ cyclotriphosphazene derivative is as follows (see the description), wherein R represents a compound (see the description) and is a fluorescence nanometer strip in morphology, and the partical size is 50-200 nm. The preparing method includes the steps that dry DOPO-HQ is added into tetrahydrofuran and stirred to be dissolved completely; an acid-binding agent is added, a tetrahydrofuran solution of hexachloro cyclotriphosphazene is dripped, and then ultrasonic reflux is carried out for 10-12 h; centrifugation and ultrasonic washing with acetone and distilled water are carried out to obtain the nanometer strip DOPO-HQ cyclotriphosphazene derivative. The derivative serves as a carrier for targeted drug delivery and is capable of achieving targeted medical delivery and fluorescence tracing.

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