The invention discloses a production method of 2,3,3,3-tetrafluoropropene. The production method comprises the following steps: introducing hexafluoropropene and hydrogen gas into a reactor (I) to carry out reactions in the presence of a catalyst to obtain a mixture composed of 1,1,1,2,3-pentafluoropropene, 1,1,1,2,3,3-hexafluoropropane, hydrogen fluoride, and a small amount of hexafluoropropene; subjecting the mixture to alkali washing, drying, and rectification to obtain 1,1,1,2,3,3-hexafluoropropane, hexafluoropropene, and 1,1,1,2,3-pentafluoropropene separately; circulating 1,1,1,2,3,3-hexafluoropropane and hexafluoropropene to the reactor (I), introducing 1,1,1,2,3-pentafluoropropene into a reactor (II), introducing hydrogen gas into the reactor (II) to carry out reactions in the presence of a catalyst to obtain a mixture of 1,1,1,2,3-pentafluoropropane, 2,3,3,3-tetrafluoropropene, HF, and a small amount of H2, subjecting the mixture to alkali washing, drying, and rectification so as to obtain the product 2,3,3,3-tetrafluoropropene. The production method has the advantages of simple technology, little discharge of waste gas, waste solid, and waste water, and high product yield and selectivity.