The invention relates to the technical field of dracocephalum moldavuca L compound phospholipid lipidosome, in particular to dracocephalum moldavuca L compound phospholipid lipidosome and a preparation method thereof. The dracocephalum moldavuca L compound phospholipid lipidosome comprises raw materials of phospholipid, cholesterol and dracocephalum moldavuca L extracts, wherein the mass ratio of cholesterol to phospholipid is (1:4)-(1:10), the mass ratio of the dracocephalum moldavuca L extracts to phospholipid is (1:2)-(1:6). Sizes of particles of dracocephalum moldavuca L compound phospholipid lipidosome are uniformly distributed, the stability is good, the hemolytic activity is small, the toxicity is low, the drug loading capacity is high, drug release can be better promoted, and the bioavailability is improved; meanwhile, the dracocephalum moldavuca L compound phospholipid lipidosome can be stored for 4-6 months, storage and transportation are facilitated, and the dracocephalum moldavuca L compound phospholipid lipidosome is suitable for industrial production.