The invention discloses a method for preventing eccentric wearing of a sucker rod and tube, and belongs to the field of oil industry oil production engineering. The method comprises the following steps of: determining the overall angle change rate of each well section of a construction oil well; determining the well sections provided with sucker rod centralizers and sucker rod guide devices and the number of the sucker rod centralizers and the sucker rod guide devices according to the overall angle change rate of each well section; feeding a pump tube of an oil sucking pump, an oil tube and a sucker tube suspender into the construction oil well; feeding an oil sucking pump plunger piston, the sucker rod, the sucker rod centralizers and the sucker rod guide devices into an sucker tube of the determined well section; and feeding the oil sucking pump plunger piston and the sucker rod into the sucker tube of other well sections, wherein the other well sections refer to well sections beyond the determined well section in each well section of the construction oil well. The method has the advantage that after the application to sites of more than 30 oil wells, the single-well average pump checking period of the oil well is prolonged by 307 days.