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发明公开
CN105061236A 氨基酸酯溴化盐型手性离子液体及其制备方法 失效 - 权利终止 转让

氨基酸酯溴化盐型手性离子液体及其制备方法
摘要：
一种氨基酸酯溴化盐型手性离子液体及其制备方法，所述氨基酸酯手性离子液体的通式为A+Br-，其中A+为氨基酸酯阳离子，其制备方法为：将氨基酸与甲醇、氯化亚砜在低温下反应得到氨基酸酯盐酸盐；将氨基酸酯盐酸盐和多聚甲醛、丙酮经过曼尼希反应得到氨基酸曼尼希碱；氨基酸酯的曼尼希碱与溴代烃反应得到氨基酸酯的手性离子液体。本发明制得的手性氨基酸酯离子液体具有手性物质的高选择性、手性诱导效应还具有离子液体的不挥发、无毒、无污染诸多优点，适合精细化工行业规模生产。
摘要（英）：

The invention discloses amino-acid ester bromide type chiral ionic liquid and a preparation method thereof. The general formula of the amino-acid ester bromide type chiral ionic liquid is A<+>Br<->, wherein A<+> is an amino-acid ester positive ion. The preparation method comprises the following steps: performing reaction on amino acid, methyl alcohol and thionyl chloride under low temperature to obtain amino-acid ester hydrochloride; performing mannich reaction on amino-acid ester hydrochloride, paraformaldehyde and acetone to obtain amino-acid ester mannich base; performing reaction on amino-acid ester mannich base and bromo-hydrocarbon to obtain the amino-acid ester chiral ionic liquid. The chiral amino-acid ester ionic liquid prepared through the preparation method disclosed by the invention has the advantages of high selectivity and chiral induction effect of a chiral substance, and non-volatilization, non-toxicity and no pollution of ionic liquid and is suitable for scale production of the fine chemical industry.

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