The invention discloses an application of seabuckthorn flavone in the preparation of compositions for enhancing the drug effect of opioids. Compared with applications in the prior art, the application has the advantages of substantial prolongation of the pain easing time of the opioids, enhancement of the pain easing effect of the opioids, and delaying of opioid tolerance caused by the opioids through synergism realized by common use of the seabuckthorn flavone and the opioids.