The invention belongs to the technical field of cosmetics and relates to a regional self-supplementing nutrient solution mask, having a patch substrate, especially which is provided with a plurality of hydrophobic separator lines, enabling formation of a plurality of liquid-supplementing regions. A nutrient solution supplementary device with a corresponding beautifying function is added to each liquid-supplementing region on the patch substrate. The whole mask is reasonably partitioned; the corresponding nutrient solution supplementary devices are disposed in the corresponding regions, allowing regional supplementing of nutrient solution for different parts of the human skin; meanwhile, the mask also has the advantages such as light weight, thinness, breathability and water absorption, the problem that the different parts of the human skin require different nutrient solutions for caring owing to the differences in temperature, water absorption, sensibility, caring means and skin type is solved, caring the human skin is simplified, and the needs of people for skin caring are met.