The invention discloses a corrugated carton creasing mechanism with adjustable pressure rollers. The corrugated carton creasing mechanism comprises a machine frame; supporting columns are fixed to the two sides of the middle of the machine frame; the two ends of a transverse frame are fixed to the two supporting columns; a rotary roller is hinged to the interior of the transverse frame; the middle portion of the rotary roller is a spline shaft portion; the spline shaft portion is inserted into and sleeved with spline through holes of the two rotary pressure rollers; a drive motor is fixed to the lateral wall of the transverse frame; an output shaft of the drive motor is connected with one end of the rotary roller; two long through grooves are formed in a top board of the transverse frame; supporting portions are fixed to the top face of the transverse frame; the two supporting portions are located above the two ends of the corresponding long through grooves; rotary screw rods are hinged to the two corresponding supporting portions; two limiting blocks are connected into the rotary screw rods in a screwed mode; the rotary pressure rollers are located between the two limiting blocks. The corrugated carton creasing mechanism is simple in structure, convenient to install and small in occupied space; meanwhile, the rotary pressure rollers can be adjusted as needed and do not need to be detached from the rotary roller, adjustment is convenient, and the precision is high.