The invention relates to a PICC thrombolysis apparatus. The PICC thrombolysis apparatus comprises a tee coupling (1) and two fixation wings (2) arranged on the tee coupling for fixing the tee coupling to the body of a patient, the fixation wings (2) are desensitization adhesive tapes, a first port of the tee coupling (1) is connected with a medicine liquid needle tube (3), a second port of the tee coupling is connected with one end of a normally-closed butterfly valve (4), a third port of the tee coupling is connected with a PICC conduit (7), and the other end of the normally-closed butterfly valve (4) is connected with a negative pressure pump (5) for generating negative pressure. The PICC thrombolysis apparatus simplifies a thrombolysis method, saves manpower, also improves the success rate of thrombolysis, and reduces the infection rate and the cost of the patient.