The invention provides a healthy and environmental-friendly biomass mattress provided with a loofah sponge functional layer. The mattress comprises an upper mattress layer and a lower mattress layer. The upper mattress layer is a comfortable layer filled with elastomer. The comfortable layer is wrapped by an upper fabric compound layer, a bottom lining and an upper surrounding edge. The lower mattress layer is composed of the loofah sponge functional layer and a spring core layer. The loofah sponge functional layer and the spring core layer are wrapped by a lower fabric compound layer and a lower surrounding edge. The upper surrounding edge is provided with a first extending part and a first connecting piece. The lower surrounding edge is provided with a second extending part and a second connecting piece. The first connecting piece and the second connecting piece are matched to open and close the lower mattress layer. According to the healthy and environmental-friendly biomass mattress, the natural space network structure of a loofah sponge material and the characteristic that the space network structure of loofah sponge material can be recovered after absorbing moisture are fully developed, so that the mattress has the good breathability, moisture absorption and shape retention, and meanwhile due to the design of a three-edge zipper, a user can conveniently taken out the loofah sponge functional layer to air the loofah sponge functional layer.