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CN104995208A 通过调节MELK治疗乳腺癌 失效 - 放弃专利权

通过调节MELK治疗乳腺癌
摘要：
提供了用于抑制乳腺癌细胞的生长或增殖的方法。所述方法包括以有效地抑制乳腺癌细胞的生长或增殖的量向有此需要的受试者施用MELK抑制剂，其中所述乳腺癌细胞是雌激素受体(ER)阴性的。在一些方面，所述方法包括以有效地抑制乳腺癌细胞的生长或增殖的量向有此需要的受试者施用MELK抑制剂、FoxM1抑制剂或MELK抑制剂和FoxM1抑制剂，其中所述乳腺癌细胞为雌激素受体(ER)阴性的。还提供了乳腺癌的治疗方法和鉴定可能从利用MELK抑制剂、FoxM1抑制剂或MELK抑制剂和FoxM1抑制剂的治疗中获益的癌症患者的方法。
摘要（英）：

Methods for inhibiting growth or proliferation of breast cancer cells are provided. The methods include administering to a subject in need thereof in an amount that is effective to inhibit growth or proliferation of the breast cancer cells a MELK inhibitor, wherein the breast cancer cells are estrogen receptor (ER) negative. In some aspects, the methods include administering to a subject in need thereof in an amount that is effective to inhibit growth or proliferation of the breast cancer cells a MELK inhibitor, a FoxM1 inhibitor or a MELK inhibitor and a FoxM1 inhibitor, wherein the breast cancer cells are estrogen receptor (ER) negative. Methods of treatment for breast cancer and methods of identifying patients having cancer that are likely to benefit from treatment with a MELK inhibitor, a FoxM1 inhibitor or a MELK inhibitor and a FoxM1 inhibitor are also provided.

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