The invention discloses a light guide plate and a manufacturing method for an ink-jet printing light guide plate. The light guide plate is provided with a light incoming surface, a light outgoing surface, and a lattice point surface. The light incoming surface is located on a side surface of the light guide plate, and the light outgoing surface is opposite to the lattice point surface. The lattice point surface is provided with an array composed of a plurality of ink printing lattice points, and the intervals among the lattice points decrease along with the increases of the distances from the lattice points to the light incoming surface of the light guide plate. The sizes of all lattice points remain unchanged, or the sizes of all lattice points increase along with the increase of the distances from the lattice points to the light incoming surface of the light guide plate and the intervals among the lattice points remain unchanged. The invention also discloses printing ink for the lattice ink-jet printing of the light guide plate, and particles of the printing ink comprise PMMA or an organosilicone microballoon wrapping layer, and titanium oxide or calcium carbonate nano solid sphere particles wrapped by the PMMA or an organosilicone microballoon wrapping layer. According to the invention, the optical effect and machining efficiency of the light guide plate can be optimized.