The invention provides a light-energy high-efficiency anti-drug-resistant-bacterium disinfectant composition and an application thereof. The disinfectant composition comprises a liquid disinfectant and a light source. The disinfectant comprises the components of, by weight, 0.000001-99% of a photosensitizer amino acid zinc phthalocyanine and derivative thereof, and balance of salt water with a salt content of 0.9%. The light source is an appropriate laser light source, LED light source or natural light. With the disinfectant liquid provided by the invention, various pathogens including drug-resistant pathogens can be rapidly and highly efficiently killed. Compared to common disinfectants, with the disinfectant composition, pathogens can be highly efficiently killed, and no drug resistance is caused. Also, the disinfectant is actually nontoxic and noncorrosive. The disinfectant does not irritate skin and mucosa. The disinfectant composition can be used for preventing various infections caused by pathogens and especially drug-resistant pathogens in hospitals and communities.