The invention discloses an application method of parametric simulation in safety assessment of a bridge grab ship unloader. The method comprises the following steps: simplifying a model, and selecting a unit type and a coordinate system; creating a parameterized model; parameterizing boundary conditions; parameterizing intensity analysis and modal analysis, and parameterizing a result viewing process; guiding a stress test and a vibration test according to the intensity analysis and the modal analysis, and comparatively analyzing an intensity analysis result, a modal analysis result and a stress test result respectively; and building a parametric simulation analysis system for the bridge grab ship unloader. According to the practical demand on the safety assessment of the bridge grab ship unloader, a VB development tool is combined with a parameterization technology of ANSYS, and modeling, the boundary conditions, an analysis process, result viewing and the like are parameterized with the parameterization technology to develop a set of parametric simulation analysis system for the bridge grab ship unloader, so that simulation analysis has the characteristics of high speed, accuracy, high practicability and the like.