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发明授权
CN104878083B 检测FOLFOX化疗药物对于结直肠癌有效性的试剂盒 有权

检测FOLFOX化疗药物对于结直肠癌有效性的试剂盒
摘要：
本发明涉及用于检测FOLFOX化疗药物对于结直肠癌有效性的试剂盒，包括一对检测MAP4K1基因拷贝数的扩增引物序列，一对检测CDKL4基因拷贝数的扩增引物序列以及一对检测内参基因GAPDH基因拷贝数的引物序列。通过本发明设计的试剂盒，可以快捷有效的对FOLFOX化疗药物对于结直肠癌有效性进行检测，评价该待检患者是否适合应用奥沙利铂作为一线化疗药物，为临床用药提供了有效的参考。
摘要（英）：

The invention relates to a kit for detecting effectiveness of a FOLFOX chemotherapy drug to colorectal cancer. The kit comprises a pair of amplification primer sequences for detecting MAP4K1 gene copy number, a pair of amplification primer sequences for detecting CDKL4 gene copy number and a pair of primer sequences for detecting reference gene GAPDH gene copy number. Through the kit designed in the invention, effectiveness of a FOLFOX chemotherapy drug to colorectal cancer can be detected rapidly and effectively, and whether a patient to be detected is suitable to use oxaliplatin as a first-line chemotherapy drug is evaluated. The kit provided by the invention provides effective reference for clinical medication.

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