The present invention provides a comprehensive advanced treatment method for papermaking wastewater. The method mainly comprises the following steps: sequentially filtering the papermaking wastewater through a grating and a cross grain filter screen; carrying out air floating treatment on the wastewater; treating the wastewater by virtue of a contact oxidation method and an activated sludge process; and finally filtering the wastewater by virtue of a fiber filter and an ultrafiltration device and treating the wastewater by virtue of a reverse osmosis device to obtain pure water. Through use of the method and comprehensive deep treatment, severely-polluted papermaking wastewater is gradually purified to obtain pure water which can be used for drinking, foods, softened water for a boiler and can be recycled to pulping, mixing pulp, cleaning the screen of a paper machine and the like by 100%, so that resource utilization of the wastewater is realized. The method provided by the present invention is used for advanced treatment and purifying the papermaking wastewater to obtain pure water, so that the situation of shortage of water resources in China will be greatly alleviated.