Methods and apparatus are provided for transmitting and receiving control information, for interference detection by a User Equipment (UE), in a wireless communication system. A base station determines whether the UE supports interference-aware detection. When the UE supports interference-aware detection, the control information is generated that includes interference signal modulation scheme information and demodulation reference signal measurement information. The control information is transmitted to the UE. The interference at the UE is measured based on the received control information.