The invention discloses an urban rail transit passenger travel guidance system under operation interruption and application thereof, and belongs to the field of transportation. The system comprises a mobile client side with a corresponding application program, a rail transit station passenger information issuing terminal, an emergency disposal department decision support terminal, a data transmission network and a central server for large-scale path search calculation. A method includes the steps that the central server quickly calculates the passenger reachable travel path set, the operation interruption influence range and the influence degree under operation interruption through the developed application program, the passenger reachable travel path set, the operation interruption influence range and the influence degree are transmitted to the emergency disposal department decision support terminal through the data transmission network, and travel path information is transmitted to the corresponding rail transit station passenger information issuing terminal and the corresponding mobile client side through the data transmission network. By the adoption of the system and method, on one hand, the information issuing decision support in an emergency is provided for a rail transit operation department, and on the other hand, the travel guidance information service is provided for passengers.