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发明授权
CN104725345B 一种2‑噻吩乙酸的清洁生产工艺 有权 转让

一种2‑噻吩乙酸的清洁生产工艺
摘要：
本发明涉及化学有机合成领域，具体提供了一种反应条件温和、环保的2‑噻吩乙酸的制备方法，以2,2,6,6‑四甲基哌啶氮氧化物(TEMPO)或其衍生物为催化剂，2‑噻吩乙醇被次氯酸钠、亚氯酸钠等氧化剂氧化制备2‑噻吩乙酸；该工艺具有反应条件温和，反应选择性高(95%)、转化率高(100%)、收率高(85%)等特点，且易于工业化操作。
摘要（英）：

The invention relates to the chemical organic synthesis field and particularly discloses a method for preparing environment-friendly 2-thiopheneacetic acid with mild reaction condition. The 2-thiopheneacetic acid is prepared by taking 2, 2, 6, 6-tetramethyl piperidine nitrogen oxide (TEMPO) or the derivative as a catalyst and oxidizing 2-thiophene-ethanol through an oxidant such as sodium hypochlorite and sodium chlorite. The process is mild in reaction condition, high in reaction selectivity (95%), high in conversion rate (100%), high in yield (85%) and easy to be industrially operated.

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