The invention provides a method of dynamically determining a cooperative cell, which is applied to a wireless communication system comprising a user terminal, a base station and a central control node. The method comprises steps: a collection of candidate cooperative collection division schemes which can be overlapped is generated; the system and the rate of each candidate cooperative collection division scheme are estimated; and a candidate cooperative collection division scheme with the maximal system and the maximal rate is selected to serve as the optimal cooperative collection division scheme. Preferably, the above step of estimating the system and the rate of each candidate cooperative collection division scheme comprises sub steps: each cooperative collection in the candidate cooperative collection division schemes and each rate are estimated; and all cooperative collection in the candidate cooperative collection division schemes and all rates are accumulated for calculating the system and the rate. The method of dynamically determining the cooperative cell of the invention integrates all strong points of each cooperative method, the best transmission rate is provided for central uses and edge users in the cell, and transmission and the rate of the overall system are maximized.