The invention discloses a production method of X65M pipeline steel. The production method includes the following steps of smelting, continuous casting of a sheet billet, heating, dephosphorization, recrystallization zone controlled rolling, cooling non-recrystallization zone controlled rolling, controlling cooling and tempering. The chemical component system of the pipeline steel is reasonably designed, the two-stage controlled rolling and controlled cooling process under low-temperature high pressure conditions is adopted, the starting rolling temperature, finish rolling temperature, starting cooling temperature, finish cooling temperature, cooling speed and other process parameters are controlled, a mixture with granular bainite and ferrite is obtained and is fine in grain and good in low-temperature rigidity, and therefore batched production of large-wall-thickness and high-steel-stage pipeline steel is realized, and meanwhile it is guaranteed that produced pipeline steel is high in rigidity and low in production cost.