The invention relates to the technical field of drugs for skin diseases, in particular to acne cream and a preparing method thereof. The acne cream is made from terbinafine hydrochloride, rifampicin, clindamycin, borneol, puerarin powder, poria cocos powder and dandelion. By means of compatibility of medicines contained in the acne cream, the acne cream can comprehensively treat pathomycete, bacteria and viruses which cause acne in the view of Western medicine and heat, poison and dampness which cause acne in the view of traditional Chinese medicine, treatment effect is thorough and remarkable, and patients who have acne can be cured comprehensively at low cost within a short period of time so as to return to normal life. Furthermore, the preparing method of the acne cream enables the treatment effect of the acne cream to be guaranteed, operation is easy, production cost is low, and the acne cream is convenient to carry and take.