The present invention provides a drive method and a drive device of a liquid crystal display, and the drive method comprises: receiving an image to display; employing the original gray scale values of the respective primary color components of the respective image pixels of the image to display to respectively generate a first display gray scale value and a second display gray scale value; employing the first display gray scale value and the second display gray scale value to respectively control display brightnesses of two display pixels of the same color on a liquid crystal panel, wherein the first display gray scale value is larger than the second display gray scale value. With the aforesaid arrangement, the present invention can reduce the color washout under large view angle to promote the display effect of the large view angle.