The invention discloses a fuze isolation mechanism which comprises a frame, and a first U-shaped separator, a second U-shaped separator, a first spring and a second spring which are arranged in the frame, wherein the two springs are two-way shape memory alloy materials; the first spring is longitudinally connected with the first U-shaped separator; the second spring is transversely connected with the second U-shaped separator; notches of the two separators are opposite to each other and are embedded into a whole in a dislocated mode under the action of the compressing force of the two springs, so that fuze isolation is realized; after the second spring and the first spring are sequentially electrified, the second U-shaped separator is pulled to transversely move by virtue of the retractive force generated by the second spring, and the first U-shaped separator is pulled to longitudinally move by virtue of the retractive force generated by the first spring, so that fuze isolation is released; and after the power of the first spring and the second spring is sequentially cut off, the first U-shaped separator and the second U-shaped separator are sequentially reset to the fuze isolation state. According to the fuze isolation mechanism disclosed by the invention, reliable switching between the isolation release state and the isolation state is realized, and the problem that the conventional fuze isolation mechanism is low in restorability and low in safety coefficient is solved.