The invention relates to a titanium alloy profile extrusion anti-oxidation and lubrication method which comprises the following steps: carrying out turning or abrasive blasting on the surface of a titanium alloy billet, degreasing the billet, heating to 50-200 DEG C, coating the surface of the billet with an anti-oxidation galas frit, and transferring the billet to a heating furnace for heating and thermal insulation; putting a glass lubricant and a binder into a glass mat manufacturing die and tightly pressing so as to obtain a glass mat; passing the glass mat through an extrusion container, and guaranteeing that the glass mat fits with an end face of the die before putting the glass mat into the extrusion die; gripping the thermal-insulated titanium alloy billet to roll one or two circles on a work plane, on which a glass lubricant exterior powder is laid, so as to make the surface of the billet to be uniformly glued with the glass powder; and filling the extrusion container and beginning titanium alloy profile extrusion. The method provided by the invention remarkably inhibits an oxidation layer from expanding towards the inside of the billet during the titanium alloy profile extrusion process, and there is a good lubrication effect among the metal surface of the billet, the extrusion container and the die.