The purpose of the present invention is to provide a polyamide hollow fiber membrane having such properties that the transmission of fine particles through the membrane can be prevented effectively, the membrane has an excellent water transmissibility, the entire surface of the membrane has excellent hydrophilicity, and impurities such as metal elements are rarely eluted through the membrane. A polyamide hollow fiber membrane produced by a TIPS method under specific production conditions has the following characteristic properties: (1) the contact angle of water on the surface of the membrane is 80 degrees or less; (2) the external pressure water transmissibility of the membrane is 50 L/(m2.atm.h) or more; and (3) the 50 nm-particles blocking ratio of the membrane is 90% or more.