The invention discloses an artificial rock core containing natural rock as well as a manufacturing method and a molding mould of the artificial rock core, belonging to the technical field of underground reserve of petroleum and natural gas. The artificial rock core comprises the irregular natural rock and a coating agent, wherein the natural rock is wrapped by the coating agent. The method comprises the steps of selecting the natural rock; putting the natural rock into the molding mould; injecting the coating agent into the molding mould; placing to enable the coating agent to be solidified and bonded with the natural rock; demoulding to obtain an intermediate product; cutting the intermediate product to obtain the standard rock core which is in accordance with the dimensional requirement. The mould comprises a containing space, wherein the diameter of the containing space is equal to that of the standard rock core to be manufactured, and the length of the containing space is more than that of the standard rock core to be manufactured. According to the artificial rock core manufactured by the method and the mould, the natural rock is wrapped by the coating agent, so that the artificial rock core contains the natural rock, the specification of the artificial rock core is the same as that of the standard rock core, and the permeability of the natural rock in the middle of the artificial rock core can be tested on a tester in a room.