The invention provides a digital pre-distortion method and device. The method comprises the following steps: obtaining the amplitude, power and quantity of a service signal collected in real time; according to the obtained amplitude, power and quantity of the service signal, judging whether the service signal is a training sequence signal or not; when the service signal is the training sequence signal, using the service signal for digital pre-distortion. The technical scheme can effectively cover the status differences and the diversity of a base station and a transmitter during working in an outfield and furthest saves limited system processing resources. The technical scheme contains the optimal sequence acquisition function under the FDD non-full service situation, fully ensures the coverage of a training sequence for the service signal on the aspects of peak amplitude and average power distribution, overcomes the defects of the traditional technology on the aspect of training sequence generation and the service feature matching while greatly reducing the computational complexity of the system, and improves the DPD processing performance.