The invention relates to a soft-foundation conformal uniform light irradiation photodynamics therapy device. Area of a treated patient is acquired by performing three-dimensional reconstruction on a body surface focus area, a contact face is made by a high-transparency soft-foundation material such as flexible silica gel, and therapy light is guided in by optical fibers and uniformly distributed by a light uniformizing plate and transparent liquid. The soft-foundation conformal uniform light irradiation photodynamics therapy device can be accurately fitted with the focus area, number of the optical fibers, power of the therapy light and wavelength of the therapy light can be changed according to therapy needs, different requirements on body surface photodynamics therapy are met, and therapy effect is improved.