The invention relates to a software running method and system based on voice interaction. Software and a voice assistant are run independently, wherein the voice assistant acquires execution item information about software running and matches a voice recognition conversion result with the acquired execution item information, and then the software operates and executes the matched execution item information according to execution item element information, execution item status information and voice information. According to the software running method and system based on voice interaction, the software is run and used according to the real-time execution item information of the software, so that the voice software trends to intellectualization truly; meanwhile, since the voice assistant and the software are run separately and independently, one voice assistant can be used in cooperation with multiple pieces of software, and system resources are greatly saved; besides, a voice engine can be updated and innovated conveniently, and intelligent development of the voice technology is promoted.