The embodiment of the invention provides a comprehensive evaluation method and system for resource optimization configuration of a power distribution network. The method comprises the following steps: creating a comprehensive evaluation index system for resource optimization configuration of the power distribution network, wherein the comprehensive evaluation index system includes a plurality of indexes; performing resource optimization configuration on the power distribution network according to distributed power organization form optimization configuration, short-circuit current limitation measure optimization configuration and synchronous phase measurement unit (PMU) distribution optimization configuration to obtain a predetermined number of optimization configuration schemes; determining an evaluation index value of each optimization scheme according to the comprehensive evaluation system for resource optimization configuration of the power distribution network; comprehensively evaluating each optimization configuration scheme by a grey correlation analysis method according to the evaluation index value of the corresponding optimization scheme to obtain grey correlation degree of each optimization scheme, and taking the optimization configuration scheme with highest grey correlation degree as an optimal optimization configuration scheme. According to the comprehensive evaluation method and system, the evaluation result is relatively objective and relatively credible.