The invention relates to an intelligent check anti-maloperation method based on a real-time trend. By taking an electric power system model, a figure and real-time operation mode data as a basis, an intelligent anti-maloperation check program, before a dispatcher performs power network control, according to a current power network model and a running state, rapidly and automatically carries out a series of checks including a basis operation rule check, a dispatcher trend calculation check and a backup automatic switching rule check, wherein the basis operation rule check covers five universal protection rules and a topology check rule, and can carry out anti-maloperation check on equipment, an interval, a whole station and even a whole network; the dispatcher trend calculation check, through dynamic trend calculation, monitors the voltage and current values of a transformer, a bus and a line and gives a prompt about operation leading to off-limit; and the backup automatic switching rule check has an additional secondary equipment check function on the basis of a primary equipment check and provides comprehensive intelligent anti-error check information, such that the safety of scheduling work is improved, and emote maloperaiton can be effectively avoided.