The invention discloses a design method of a science and art integrated mountain and river three-dimensional perspective landscape map. The design method comprises the steps: I establishing a three-dimensional perspective terrain framework, and II carrying out colored drawing after amplifying a foundation drawing. The landscape map designed by the method can reflect elements and characteristics of a terrain visually, systemically, completely and typically, and the map becomes a comprehensive achievement integrating scientificity, knowledge, interestingness, artistry and commodity.