The invention discloses a preparation method for efficiently purifying phacolysin bulk drugs. The preparation method for efficiently purifying phacolysin bulk drugs comprises the following processes: preparing a coarse phacolysin bulk drug solution, performing resin adsorption, performing resin dilute alkali solution elution, collecting the eluate, performing reduced pressure evaporation concentration, and performing vacuum drying, thereby obtaining the product. The method disclosed by the invention has the advantages that the coarse phacolysin solution is subjected to resin adsorption by using macroporous resin, elution is performed in a dilute alkali solution, and the phacolysin bulk drugs with the purity of more than 98 percent can be prepared. The method is easy to operate, simple in process flow, low in cost and suitable for batch production.