The invention discloses an anti-radiation D flip-flop circuit based on three mutual-latching units. The anti-radiation D flip-flop circuit comprises a clock signal generation circuit, a D input filter circuit, C unit circuits, a voting circuit, a primary mutual-latching circuit and a secondary mutual-latching circuit. The C unit circuits include a first C unit circuit, a second C unit circuit and a third C unit circuit. Clock signals are generated after an external clock signal CK passes through the clock signal generation circuit, data signals are generated after an external data signal D passes through the D input filter circuit, data signals, output after the clock signals and the data signals pass through the primary mutual-latching circuit, the secondary mutual-latching circuit and the C unit circuits, passes through the voting circuit to output an output signal Q of a whole flip-flop. The anti-radiation D flip-flop circuit has the advantages that a three mutual-latching circuit reinforcement technology is adopted, output stability and reliability of the whole D flip-flop circuit can be guaranteed in case of overturning of the D flip-flop circuit due to interference such as radiation, and anti-radiation capability of the D flip-flop circuit is greatly improved.