The invention discloses a common-mode feedback differential amplification circuit, a method and an integrated circuit. The method comprises the following steps: a common-mode feedback (CMFB) loop generates a second common-mode signal and a third common-mode signal by dividing voltage of a first common-mode signal; a differential amplifier sets up the condition that the voltage of one of the second common-mode signal and the third common-mode signal with higher voltage is equal to the voltage at a first input end or a second input; the CMFB loop controls the differential amplifier to output an output signal with the lowest voltage equal to the voltage of the first common-mode signal according to the negative feedback principle. Through the adoption of the scheme in the invention, when processing the second common-mode signal and the third common-mode signal at the input stage, the differential amplifier is not required to be connected with a high-voltage power supply; in addition, the voltage between the output signals is not required to be conducted with resistance voltage dividing to realize common-mode feedback, so as to reduce the power consumption.