The invention relates to a method for preparing a dual-factor carrying type hybrid bionic bone scaffold and application of the dual-factor carrying type hybrid bionic bone scaffold. The preparation method comprises the following steps: immersing a calcium- silicon hybrid bionic bone scaffold in fibers in a chemotactic factor-osteogenesis inducing protein mixed solution with proper concentration; treating under a proper condition to obtain the dual-factor carrying type hybrid bionic bone scaffold. The related application is application of the scaffold material in a bone defect repairing material. The hybrid ossein contains silicon dioxide and hydroxyapatite two minerals, wherein due to the effective combination of massive negative charge-loaded silanol groups existing on the surface of the silicon dioxide and active hydroxyl radicals on basic protein such as SDF-1 or TGF-beta and the specifically strong adsorptivity of nano-hydroxyapatite on osteogenesis induced protein, such as BMP-2 or BMP-7, an extra sustained-release system need not to be added, and hybrid osteocyte recruitment/osteogenesis induction double functionalized modification can be realized.