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发明公开
CN104288149A 4-氯-2-(5-苯基-1-(吡啶-2-yl)-4,5-二氢-1H-吡唑-3-yl)苯酚在制药中的应用 失效 - 权利终止

4-氯-2-(5-苯基-1-(吡啶-2-yl)-4,5-二氢-1H-吡唑-3-yl)苯酚在制药中的应用
摘要：
本发明公开了一种4-氯-2-(5-苯基-1-(吡啶-2-yl)-4,5-二氢-1H-吡唑-3-yl)苯酚在制备抑制脂肪肝和稳定动脉硬化斑块药物中的应用；其中：有效抑制脂肪肝和稳定动脉硬化斑块的4-氯-2-(5-苯基-1-(吡啶-2-yl)-4,5-二氢-1H-吡唑-3-yl)苯酚剂量为5-20μg/kg/day。本发明提供的4-氯-2-(5-苯基-1-(吡啶-2-yl)-4,5-二氢-1H-吡唑-3-yl)苯酚为研制治疗脂肪肝和动脉硬化的药物奠定了基础，并可作为脂质代谢异常和动脉硬化斑块不稳定的分子机制研究的有力工具。
摘要（英）：

The invention discloses application of 4-chloro-2-(5-phenyl-1-(pyridine-2-yl)-4, 5-dihydro-1H-pyrazol-3-yl) phenol in preparation of medicaments for inhibiting fatty liver and stabilizing atherosclerotic plaques. The dose of 4-chloro-2-(5-phenyl-1-(pyridine-2-yl)-4,5-dihydro-1H-pyrazol-3-yl) phenol for effectively inhibiting the fatty liver and stabilizing the atherosclerotic plaques is 5-20mu g/kg/day. 4-chloro-2-(5-phenyl-1-(pyridine-2-yl)-4, 5-dihydro-1H-pyrazol-3-yl) phenol provided by the invention lays a foundation for development of the medicaments for treating the fatty liver and arteriosclerosis and can be used as a powerful tool for researching a molecular mechanism of abnormal lipid metabolism and unstable atherosclerotic plaques.

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