The invention discloses a mine ventilation system building method based on DIMINE software. According to the method, a mine ventilation system three-dimensional model is built through the DIMINE software; the DIMINE file format of the built ventilation system three-dimensional model is converted into a file format compatible with 3DVent software; according to the ventilation network resolution technology requirements, the mine ventilation network resolution work is completed through combining the actual conditions of a mine; according to the ventilation network resolution result, the mine ventilation system design and modification scheme optimization work is completed; according to the ventilation network resolution result, the three-dimensional visualization and air flow animation simulation software realization technology study of the ventilation network resolution result is developed; and the real three-dimensional visualization and air flow animation simulation of the mine ventilation network resolution result is realized. The method has the advantages that the resolution step is simplified; the work efficiency and the accuracy are improved; the electric energy can be saved; the ventilation cost is reduced; the underground microclimate conditions are improved; and a good operation environment is created for underground workers.