The invention discloses a method and device for determining a physical address and relates to the technical field of computers. A TLB supporting connection of groups of various page sizes can be adopted for acquiring the physical address and power consumption is reduced. The method includes the steps that according to a high N bit of a linear address, the page size is acquired, wherein N is larger than 0 and smaller than the bit of the linear address; according to the page size, an index number, converted and cached by a bypass, of the TLB is acquired; according to the page size and the supported minimum page size, a Mask bit is acquired; according to the Mask bit, a label of the TLB is acquired; According to the index number and the label, the TLB is searched for, and a high MAC1 bit of the physical address corresponding to the linear address is acquired; according to the Mask bit, the supported minimum page size and the high MAC1 bit of the physical address, the physical address is acquired. The method and device are suitable for determining the physical address through the linear address.