The invention belongs to the technical field of materials for infusion bottles or bags and discloses a self-lubrication composite material used for producing easy-folding outer covers of infusion bottles or bags and the application of the self-lubrication composite material in the medicine packing materials. By weight, the self-lubrication composite material comprises the following components: 55-94 parts of polypropylene, 1-20 parts of polyethylene, 1-20 parts of flexibilizers, 2-25 parts of lubrication resin and 0.1-4 parts of antioxidants. The lubrication resin is composed of at least one of ethylene, norbornene copolymer, 1,1,2,3,3,3-hexafluoropropylene-1-propylene and 1,1-polyvinylidene floride copolymer master batches. Polypropylene is adopted as the main material so that the self-lubrication composite material can ensure the welding intensity. The lubrication resin and the substrate have good compatibility so that the self-lubrication composite material has good temperature resistance, biological fitness, chemical inertness and high lubricity, enables the static friction coefficient to be as low as 0.381, the dynamic friction coefficient to be as low as 0.343, and the yellow color index after 25 kGy doses of 60 Co-gamma ray radiation to be smaller than and equal to 9.