The invention relates to small molecular donkey-hide gelatin pure powder tablets and a preparation method thereof. The small molecular donkey-hide gelatin pure powder tablets take small molecular donkey-hide gelatin as a raw material for the first time, and are processed into tablets without any auxiliary material (the tablets being lozenge tablets or swallowing tablets except for specific explanation). The appearance and hardness of the tablets meet quality standards of tablets. The small molecular donkey-hide gelatin pure powder tablets take 10-30 meshes of small molecular donkey-hide gelatin that contains 2-15 wt% of water and 2-9 wt% of total sugar as a sole raw material and obtained by directly tabletting. The tablets prepared by the preparation process have low granulating rate and lobes rate and good appearance, with hardness, disintegration and friability of the tablets meeting the quality requirements of tablets. The small molecular donkey-hide gelatin pure powder tablets are easy to carry, convenient for taking and accurate in dosage, thereby enlarging suitable population of the donkey-hide gelatin.