The invention discloses a pneumatic control combination valve and an application method thereof. The pneumatic control combination valve comprises a valve body, covers hermetically connected to two ends of the valve body, an intake assembly and an exhaust assembly arranged in the valve body, and a heating plate. The intake assembly comprises an intake piston rod, two intake pistons symmetrically installed at two ends of the intake piston rod and an intake sliding sleeve. The exhaust assembly comprises an exhaust piston rod, an exhaust piston, an exhaust piston sleeve, a guide block, a sealing block, a reset spring and an exhaust sliding sleeve. The pneumatic control combination valve provided by the invention is convenient to install and maintain, and has no exposed control air pipes, so that the whole modularized adsorption drier is concise, elegant and compact in structure, and intelligent and automatic control is convenient to achieve. The pneumatic control combination valve, with one muffle less and one heating plate less, has no connection of control air pipes and no leakage of air pipe joints, provides a fault detection signal source for a subsequent drier fault automatic processing device, and is reduced in energy consumption, and lowered in whole valve cost.