The invention discloses a preparation method of a high-wear-resistant copper alloy wire for an automobile. The preparation method comprises the following elementary components in percentage by weight: 4.5-6.5% of Al, 2.2-3.6% of Fe, 1.4-1.8% of Mn, 1-1.5% of Si, 0.6-1.2% of Ni, 0.4-0.8% of Cr, 0.3-0.5% of W, 0.15-0.25% of V, 0.1-0.2% of Co, 0.05-0.15% of B, 0.03-0.06% of Te, 0.02-0.04% of Ce, 0.01-0.02% of Pm and the balance of copper and unavoidable impurities. The copper alloy wire prepared by using the preparation method is excellent in wear resistance, high in strength, good in corrosion resistance, resistant to fatigue, ageing and scrubbing, durable in use and wide in application prospect.