知搜-全球专利检索

  1. 登录
  2. 注册
发明授权
CN104053452B 用于抑制经由胰岛素样生长因子-1的细胞活化的方法 失效 - 权利终止

用于抑制经由胰岛素样生长因子-1的细胞活化的方法
摘要：
抑制有其需要的个体（例如患有癌症、动脉粥样硬化、糖尿病视网膜病变或其他疾病的个体）中经由胰岛素样生长因子‑1（IGF‑1）的细胞活化的方法，其包括向所述个体以有效抑制经由IGF‑1的细胞活化的量施用抑制IAP与SHPS‑1的结合的拮抗剂。还描述了用于实施此类方法的化合物和组合物。
摘要（英）：

A method of inhibiting cellular activation by insulin-like growth factor-1 (IGF-1) in a subject in need thereof (e.g., a subject afflicted with cancer, atherosclerosis, diabetic retinopathy or other disease) comprises administering an antagonist that inhibits the binding of IAP to SHPS-1 to the subject in an amount effective to inhibit cellular activation by IGF-1. Compounds and compositions for carrying out such methods are also described.

公开/授权文献
0/0