In embodiments of host side implementation for HID I2C data bus, a computing system includes a human interface device (HID) software stack that implements device software, such as for embedded devices, that interfaces the computing system to a peripheral device via HID over I2C. An HID I2C driver interfaces the HID software stack with the peripheral devices that each include an HID I2C interface to a device that communicates data in the computing system via an I2C data bus. The HID I2C driver is compatible and interfaces with I2C controller drivers and GPIO controller drivers of the devices, where the I2C controller drivers and the GPIO controller drivers may each have a different implementation configuration.